Nav1.5 screening in hiPSC-derived cardiomyocytes
Human induced pluripotent stem cells (hiPSC) hold much promise for advances in biomedical research (see our recent review here).
Sophion Bioscience has been leading the field in automated patch clamp recordings in hiPSC-derived cardiomyocytes (hiPSC-CMs – with a webinar on this here)
With developments in the Comprehensive in vitro Proarrhythmia Assay (CiPA) & the FDA Modernization Act calling for improved human model drug discovery assays and an increasing need to reduce animal testing, higher throughput cardiac ion channel assays in hiPSC-CM are in demand.
In our latest Application Report, Stefania Karatsiompani and Beatrice Badone developed a QPatch II automated patch clamp cardiac huNav1.5 ion channel screening assay on hiPSC-CM, made by collaborators iBET.
See these developments in cardiac ion channel safety pharmacology here.