Bellin et al 2012
Large molecules such as venom, toxins and peptides, wnt peptides,
knotbodies, nanobodies and antibodies are characterized by automated pathc clamping and are increasingly becoming important in drug discovery.
Venom, toxins and peptides are highly potent and specific to individual ion channels.
Venom, toxins and peptides are widely used tools in research to elucidate structure and function of ion channels
Cross section of QPlate
Whole-cell P2X3 receptor current responses to four successive exposures to 20 μM CTP. Between each agonist application, the cell was washed with saline. The responses were highly reproducible. The peak current was identified in the cursor range between 3000 and 5000 ms. Inset shows a corresponding current recording obtained with manual patch clamp.
Qube with stacker
Qube with stacker
Raw current traces of CHO-hERG with accumulation doses of antagonist
Overlay of concentration response curves on CHO-hERG
Overview of Sophion Analyzer. Concentration response experiments with glutamate receptor
