Sophion develops patch-clamp amplifiers in-house. These feature automatic compensation for series resistance (Rs), cell capacitance (Cslow), and up to 300 nA maximal current measured, depending on amplifier type. This specification contributes to quality recordings that are regarded as a hallmark of Sophion products. We believe that amplifiers are so vital in obtaining reliable and reproducible ion channel recordings that we need full control, by in-house development utilizing the accumulated experience of our experts. We are convinced that our in-depth understanding of how amplifiers should be integrated into the patch-clamp instrument means that we can offer the best amplifier solution on the market.
From the platform of the screening station, a ‘bed-of-nails’ connects the patch-clamp electrodes directly with the amplifier front ends. This distance is critical and minimized to reduce any noise pick-up from the surroundings.
Multiple patch-clamp amplifiers are implemented on a standard printed circuit board, enabling all amplifiers to be positioned near the patch-clamp electrodes. Due to their small size, Sophion amplifiers are ideally suited for extensive parallelism and provide considerable scalability.
- Voltage Clamp
- Current Clamp
- Voltage and current clamp in the same sweep
- Series Resistance Compensation (Rs) (Up to 100%)
- Cell capacitance compensation (Cslow)
- Minimal noise
- Up to 300 nA maximal current