hERG compound screening at 22°C and 35°C on QPatch II
Application Report Go to journalAuthor(s):
Beatrice Badone, Stefania Karatsiompani
In this study, by using our QPatch II system and the temperature control feature, we report a significant difference in hERG kinetics at 22°C and 35°C. By testing four hERG blockers, we were able to measure channel activity and investigate compound effects at the two temperatures.
IC50 values obtained from the compounds tested on the QPatch II are similar to those obtained on the Qube 384 and agree with literature.