Sophion webinar: Automated patch clamp at physiological temperature for CyberQ-qNet-driven cardiac safety evaluation
Cardiac safety assessment is evolving rapidly, and the predictive power of modern in silico models depends heavily on the quality of the experimental electrophysiology data used to build them. This webinar brings together Sophion Bioscience and CytoCybernetics to demonstrate how high-fidelity automated patch-clamp recordings and advanced CiPA-based computational analysis can work together to improve proarrhythmia risk assessment.
Join us on June 10, 2026 (at 4:00 PM CET) for the Sophion webinar: Automated patch clamp at physiological temperature for CyberQ-qNet-driven cardiac safety evaluation.
In this two-part webinar, Dr. Patric Vaelli, Research Scientist at Sophion Bioscience, will first present how Sophion’s QPatch and QPatch Compact platforms enable high-fidelity cardiac electrophysiology recordings at physiological temperature to support reliable and CiPA-aligned cardiac safety assessment. He will highlight how optimized hardware design, reproducible seal quality, and standardized protocols reduce variability and recording artifacts while generating robust hERG data for predictive proarrhythmia risk screening.
Following this, Dr. Randall Rasmusson, President at CytoCybernetics, will demonstrate how high-quality automated patch clamp data can be integrated into CyberQ-qNet workflows for advanced in silico cardiac safety analysis. Using benchmark compounds and CiPA-based computational models, he will show how Torsade Metric Scores (TMS) can be extracted from APC-generated hERG recordings to support reliable TdP risk categorization and more informed cardiac safety decision making.
You’ll gain practical insights into generating high-quality cardiac electrophysiology data, improving assay consistency and reliability, and integrating APC data with advanced computational workflows to strengthen predictive cardiac safety assessment and CiPA-compliant proarrhythmia risk evaluation.
đź“… Date: June 10, 2026
⏰ Time: 4:00 PM CET
đź“Ť Location: Join our online Sophion webinar
What you’ll learn in the Sophion webinar:
Part 1: Automated Patch Clamp for Cardiac Safety Assessment Under Physiologically Relevant Temperature and Solution Conditions (20 min.)
- How key hardware innovations in Sophion’s APC platforms minimize noise and artifacts to deliver the clean, stable hERG recordings required for accurate cardiac safety assessment
- Why consistent, reproducible seal quality and recording conditions are critical when generating data intended for CiPA-compliant in silico modeling
- How standardized, robust protocols on the QPatch and QPatch Compact platforms reduce experimental variability and support reliable TdP risk categorization across compounds
By Patric Vaelli, Ph.D., Research Scientist at Sophion Bioscience
Part 2: Extraction of Torsade Metric Scores from Automated Patch Clamp Data (20 min.)
- How hERG APC data are processed through quality control, leak, and reference subtraction for accurate CyberQ-qNet/TMS analysis
- How in silico models extract drug-specific channel kinetics and translate them into proarrhythmia risk predictions
- How data quality and experimental design influence the reliability of CyberQ-qNet-based cardiac safety assessment
By Randall Rasmusson, Ph.D., President at CytoCybernetics
Reserve your spot and discover how advanced automated patch clamp technology and integrated in silico analysis workflows can enhance cardiac safety screening, improve data reliability, and support confident CiPA-aligned proarrhythmia risk assessment.