Diseased and control hIPSC motor neurons measured on Qube and QPatch

Motor neurons control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing. Motor neuron diseases (MND) are a group of progressive neurological disorders that destroy motor neurons. Some MNDs are inherited, but the causes of most MNDs are not known.

Being able to measure and screen on diseased and wildtype hIPS motor neurons have long been requested from many of our users.

In this new poster just presented at “Neuroscience 2018” we show that measurements on normal and diseased motor neurons are possible with good success rates on both Qube and QPatch

  • Electrophysiological properties of hiPSCs from Spinal Muscular Atrophy (SMA) or Amyotrophic Lateral Sclerosis (ALS) patients was measured and compared to their control cell lines
  • ALS disease cells exhibit a significantly increased NaV current as compared to the control, which could be rescued by a single point mutation.

Find it here