Calcium - Sophion

Cav1.2

Posters

  • View Novel first-in-class voltage-gated calcium channel positive allosteric modulators that stabilize the open state of the channel and have therapeutic potential to treat a variety of neuromuscular conditions
    Year: 2019 First author: Meriney et Al.
  • View Predicting Cardiac Proarrhythmic Risk Exclusively Using Automated Patch Clamp Data
    Year: 2019 First author: Humphries et Al.
  • View Verification of CiPA Recommended Voltage Protocols in Patch-Clamp Assay for hERG, Cav1.2 and Late Nav1.5 Currents
    Year: 2019 First author: Katayama et Al., 2019
  • View Optimization of Cardiac CiPA Targets (hCav1.2 and hKCNQ1/hminK) on the QPatch HT Automated System
    Year: 2018 First author: Koci et Al., 2018
  • View Automated High Throughput Na+ Late Current Assay on QPatch HT Platform for CiPA28
    Year: 2018 First author: Renganathan et Al., 2018
  • View Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip
    Year: 2016 First author: Schupp et al., 2016
  • View Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques
    Year: 2012 First author: Schrøder et al., 2012
  • View Are stem-cell cardiomyocytes a viable cellular reagent for automated patch-clamp?
    Year: 2017 First author: Morton

Papers

  • View Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells
    Year: 2020 First author: Kramer et Al.
  • View Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling
    Year: 2019 First author: Isobe et Al.
  • View hCav1.2 recordings on Qube 384 using step, train and CiPA protocols
    Year: 2018 First author: Schupp
  • View A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
    Year: 2015 First author: Mistry et al., 2015
  • View Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
    Year: 2015 First author: Okada et al., 2015
  • View MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
    Year: 2013 First author: Kramer et al., 2013
  • View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia
    Year: 2017 First author: Bell
  • View Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs
    Year: 2017 First author: Diness, J Goldin et Al
  • View Novel bacterial topoisomerase inhibitors derived from isomannide
    Year: 2020 First author: Okumu et Al.
  • View A big Molecule Induces Schwann cells in the peripheral nervous system leading to Myelin Sheath Repair
    Year: 2020 First author: Rozenfeld et Al.
  • View Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses
    Year: 2021 First author: Kambayashi, R et Al.
  • View Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk – One pharma’s experience and perspective
    Year: 2022 First author: Watt et al.

Reports

  • View hCav1.2 recordings on Qube 384 using step, train and CiPA protocols
    Year: 2018 First author: Schupp
  • View hCav1.2 recordings using QPatch
    Year: 2018 First author: Rosholm et Al.
  • View Cav1.2 on Qube 384
    Year: 2017 First author: Schupp, M
  • View Cav1.2 on Qube 384 – pharmacology, stability and CiPA
    Year: 2018 First author: Schupp et Al., 2018
  • View Keep it simple – Ready-To-Use Cav1.2 cells on Qube 384
    Year: 2020 First author: Schupp

Cav2.2

Papers

  • View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia
    Year: 2017 First author: Bell
  • View Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain
    Year: 2018 First author: Wall et Al., 2018
  • View Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi
    Year: 2017 First author: Sousa

Reports

  • View HEK293-Cav2.2 for QPatch
    Year: 2012 First author: Rasmus Bjørn Jacobsen

Cav3.2

Papers

  • View A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
    Year: 2015 First author: Mistry et al., 2015
  • View QPatch: the missing link between HTS and ion channel drug discovery.
    Year: 2009 First author: Mathes
  • View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia
    Year: 2017 First author: Bell

Reports

  • View HEK-Cav3.2 recordings on QPatch
    Year: 2012 First author: Jensen et al., 2012

Cav2.1

Posters

  • View Novel first-in-class voltage-gated calcium channel positive allosteric modulators that stabilize the open state of the channel and have therapeutic potential to treat a variety of neuromuscular conditions
    Year: 2019 First author: Meriney et Al.

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