Ion channels control many essential functions in the cell, including chemical signalling, regulation of pH, transcellular transport and regulation of cell volume. Abnormal function of ion channels can cause a diverse range of diseases, socalled channelopathies. The number of diseases related to ion channel malfunction are increasing and with that the amount of potential drugable ion channel targets.
A wide range of diseases are caused by ion channels
Examples of channelopathies are Cystic fibrosis (CFTRT, TMEM16), epilepsy (Kv7.2/KCNQ2), but ion channels are involved in diseases in many areas such as Cardiac, Genitourinary, Metabolic, Gastrointestinal, Stroke, Pain/Inflammation, Psychiatric Disorders, Pulmonary/Respiratory and Seizures/Convulsions. More and more evidence shows that ion channels could be a relevant target for cancer treatments as well.
Read more about automated patch clamping and channelopathies here
- View Development of a QPatch-Automated Electrophysiology Assay for Identifying TMEM16A Small-Molecule Inhibitors Year: 2020