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Channelopathies

Ion channels control many essential functions in the cell, including chemical signalling, regulation of pH, transcellular transport and regulation of cell volume. Abnormal function of ion channels can cause a diverse range of diseases, socalled channelopathies. The number of diseases related to ion channel malfunction are increasing and with that the amount of potential drugable ion channel targets.

 

A wide range of diseases are caused by ion channels

Examples of channelopathies are Cystic fibrosis (CFTRT, TMEM16), epilepsy (Kv7.2/KCNQ2), but ion channels are involved in diseases in many areas such as Cardiac, Genitourinary, Metabolic, Gastrointestinal, Stroke, Pain/Inflammation, Psychiatric Disorders, Pulmonary/Respiratory and Seizures/Convulsions. More and more evidence shows that ion channels could be a relevant target for cancer treatments as well.

 

Read more about automated patch clamping and channelopathies here

 


Papers

  • View Development of a QPatch-Automated Electrophysiology Assay for Identifying TMEM16A Small-Molecule Inhibitors
    Year: 2020 First author: Henckels et Al.
  • View Large molecules scorpion toxin block of BK channels on Qube 384
    Year: 2021 First author: Schupp et al

Reports

  • View Fast desensitizing ion channels recorded on Qube 384
    Year: 2017 First author: Sauter
  • View Fast series resistance compensation on Qube 384 and QPatch
    Year: 2016 First author: Jacobsen et al., 2016

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Sophion Bioscience A/S
Baltorpvej 154, 2750 Ballerup, Denmark
Telephone: +45 44 60 88 00

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