Ion Channels and Cancer

The transport of ions across the cell membranes plays a critical role in tumor cell functions, such as cell volume regulation, cell migration, cell cycle progression, cell proliferation and cell death. Functions that are critical for tumor cell survival as well as metastasis.
If tumor-relevant ion channels are upregulated by growth factors and hormones to the extent that a given ion channel is critically important for the survival of a tumor cell it might be considered a target for treatment. However, only ion channels applicable to the suppression of tumor growth, which do not serve critically important functions in other cells, (e.g. channels involved in cardiac repolarization) are relevant. Also, potential ion channel targets may be relevant for the proliferation and survival of cells other than tumor cells.
Several Ion Channels are currently being investigated as oncogenic or potential targets for anti-cancer drugs.
Scientific talks
‘hERG Channels: From anti-targets to novel targets for cancer therapy’,
Prof. Annarosa Archangeli, Sophion ICMS 2017,
‘Kv10.1 and the cell cycle: A two-way road’,
Dr Luis Pardo, Sophion ICMS 2017,
‘In vivo evidence for expression of voltage-gated sodium channels in cancer and potentiation of metastasis’,
Prof. Mustafa Djamgoz, Sophion ICMS 2019,
‘Targeting potassium channels in cancer from cell signaling to precision medicine’,
Prof. Saverio Gentile, Sophion User Meeting 2021,
Ion channels and cancer
Posters
- View Voltage-gated sodium channels: Multi-faceted involvement in cancer Year: 2022
Papers
- View Wnt peptides control mammalian cancer cell membrane potential Year: 2018
- View Wnts control membrane potential in mammalian cancer cells Year: 2019
- View Cancer as a channelopathy: ion channels and pumps in tumor development and progression Year: 2015
- View Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy Year: 2018
- View Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling Year: 2013
- View Voltage-Gated Ion Channels in Cancer Cell Proliferation Year: 2015
- View Synthesis and Biological Evaluation of Novel Olean-28,13?- lactams as Potential Anti-prostate Cancer Agents Year: 2015
- View Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines Year: 2019
- View Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers Year: 2018
- View Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity Year: 2020
- View Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors Year: 2017
- View Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airway Year: 2018
- View Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment Year: 2019
- View Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Year: 2021
- View Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism Year: 2017
Reports
- View Large Molecules: Wnt signal activation Year: 2022