Cancer - Sophion

Ion Channels and Cancer

Ion channels involved in cancer (click on image to enlarge)

Transport of ions across the cell membranes play a critical role in tumor cell functions, such as cell volume regulation, cell migration, cell cycle progression, cell proliferation and cell death. Functions that are critical for tumor cell survival as well as metastasis.

 

If tumor-relevant ion channels are upregulated by growth factors and hormones to the extent that a given ion channel is critically important for the survival of a tumor cell it might be considered a target for treatment. However, only ion channels applicable to the suppression of tumor growth, which does not serve critically important functions in other cells, (e.g. channels involved in cardiac repolarization) are relevant. Also, potential ion channel targets may be relevant for the proliferation and survival of cells other than tumor cells.

 

Several Ion Channels are currently being investigated as oncogenic or potential targets for anti-cancer drugs.

 

Scientific talks

‘hERG Channels: From anti-targets to novel targets for cancer therapy’,

Prof. Annarosa Archangeli, Sophion ICMS 2017,

 

‘Kv10.1 and the cell cycle: A two-way road’,

Dr Luis Pardo, Sophion ICMS 2017,

 

‘In vivo evidence for expression of voltage-gated sodium channels in cancer and potentiation of metastasis’,

Prof. Mustafa Djamgoz, Sophion ICMS 2019,

 

‘Targeting potassium channels in cancer from cell signaling to precision medicine’,

Prof. Saverio Gentile, Sophion User Meeting 2021,


Ion channels and cancer

Papers

  • View Wnt peptides control mammalian cancer cell membrane potential
    Year: 2018 First author: Ashmore et Al., 2018
  • View Wnts control membrane potential in mammalian cancer cells
    Year: 2019 First author: Ashmore et Al., 2019
  • View Cancer as a channelopathy: ion channels and pumps in tumor development and progression
    Year: 2015 First author: Litan et al., 2015
  • View Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy
    Year: 2018 First author: Zha et Al.
  • View Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
    Year: 2013 First author: Britschgi, A
  • View Voltage-Gated Ion Channels in Cancer Cell Proliferation
    Year: 2015 First author: Rao et al., 2015
  • View Synthesis and Biological Evaluation of Novel Olean-28,13?- lactams as Potential Anti-prostate Cancer Agents
    Year: 2015 First author: Ai et al., 2015
  • View Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
    Year: 2019 First author: Reyes-Corral et Al., 2019
  • View Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers
    Year: 2018 First author: Wang et Al., 2018
  • View Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity
    Year: 2020 First author: Kuramoto et Al.
  • View Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors
    Year: 2017 First author: Huang
  • View Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airway
    Year: 2018 First author: Miner et Al., 2018
  • View Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment
    Year: 2019 First author: Ong et Al.
  • View Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore
    Year: 2021 First author: Paradkar et Al
  • View Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
    Year: 2017 First author: Petrou
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