Two new posters by Charles River Laboratories on HTS ion channel screening
Using the stacked solution technology Charles River have developed and validated an assay suited for high through screening on both P2X- and GABA receptors. The short exposure of ligand of less than 1 second enables repetitive stimulation which is necessary for this assay. In another assay with voltage-gated target, the vast number of parameters that can be measured with high fidelity e-phys makes it important that the underlying software is powerful enough to cope. Read more here for ligand-gated and here for the NaV1.1 assay.