Pharmacological manipulation of the GABA ion channel has a large potential. The central role of GABA in the nervous system is underscored by the devastating consequences of pathophysiological changes in GABA signalling. Conversely, manipulation of GABA receptors can offer relief of a large group of neurological and psychiatric disorders.
GABA mediated currents elicited by optical uncaging in both a concentration and light dependant fashion.
QPatch studies on voltage- and current clamp recordings on Cor.4U human iPS cell-derived cardiomyocytes