Cancer cell membrane potential controlled by Wnt peptides
Wnt ligands play important functional roles during development and in disease. Binding of Wnt to the cell membrane receptors which starts a signalling pathway was made by using QPatch and single cell patch recording.
The findings suggest that Wnt control of membrane potential is a signal amplifying mechanism for low nanomolar levels of Wnt, and modulation of this cell signal transduction pathway could be critical for gene transcription and cellular function. See the poster here.