Sodium channels
Sodium channels are highly selective for the transport of sodium ions across cell membranes.
Sodium channels are associated with a large range of channelopathies among others epilepsy, Dravet syndrome, West syndrome, Irritable bowel syndrome, long QT syndrome, neuropsychiatric disorders, pain and insensitivity to pain.
Multiple Na Channels
Posters
- View Biophysical and pharmacological characterization of multiple Nav subtypes on Qube Year: 2016
- View Sophion analyzer as a tool for biophysical and pharmacological characterization of eight Nav subtypes evaluated in parallel on Qube Year: 2016
- View Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT Year: 2016
Nav1.1
Posters
- View HT Automation for patch clamp based primary screen for Nav1.1 using Qube 384 Year: 2018
Papers
- View The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/− mice Year: 2017
- View A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo Year: 2017
- View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia Year: 2017
Reports
- Nav1.1 currents on Qube Year: 2018
Nav1.2
Posters
- View Biophysical and pharmacological characterization of multiple Nav subtypes on Qube Year: 2016
- View Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT Year: 2016
- View Data quality is not affected by cell suspension density Year: 2006
- View Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques Year: 2012
- View Evaluation of throughput and data quality Year: 2009
- View Pharmacological characterization of voltage- and ligand-gated ion channels Year: 2006
Papers
- View Automated Patch Clamping Using the QPatch Year: 2009
- View Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels Year: 2009
- View QPatch: the missing link between HTS and ion channel drug discovery. Year: 2009
- View Stable response for ligand and voltage-gated ion channels on QPatch Year: 2010
- View 4-Substituted carbamazepine derivatives: conformational analysis and sodium channel-blocking properties
- View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia Year: 2017
Reports
- View Voltage-gated sodium channels on QPatch 16 Year: 2012
Nav1.3
Posters
Papers
- View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia Year: 2017
Nav1.4
Posters
Papers
- View Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels Year: 2009
- View The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake Year: 2016
Reports
- View High throughput screening for mode-of-action on Nav1.4 Year: 2017
Nav1.5
Posters
- View Biophysical and pharmacological characterization of multiple Nav subtypes on Qube Year: 2016
- View Electrophysiological properties of iCell cardiomyocytes obtained by automated patch clamp Year: 2011
- View Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip Year: 2016
- View Use- and state-dependent Nav1.5 blockers on QPatch X and in vivo and in vitro assays Year: 2010
- View Rapid generation of cells for ion channels assays: Efficient, large scale transfection using the MaxCyte STX
- View Enhancing throughput with multiple cell lines per well
- View Nav1.5 use-dependent blockers on QPatch X Year: 2012
- View Are stem-cell cardiomyocytes a viable cellular reagent for automated patch-clamp? Year: 2017
Papers
- View Eleclazine exhibits enhanced selectivity for long QT syndrome type 3–associated late Na+ current Year: 2017
- View Use- and state-dependent Nav1.5 blockers on QPatch X and in vivo and in vitro assays Year: 2010
- View Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels Year: 2009
- View MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes Year: 2013
- View A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment Year: 2015
- View Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator Year: 2015
- View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia Year: 2017
- View Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation Year: 2017
- View Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs Year: 2017
Reports
Nav1.6
Posters
Nav1.7
Posters
- View “Clip Detecting” with series resistance compensation using an automated patch clamp system Year: 2012
- View Biophysical and pharmacological characterization of multiple Nav subtypes on Qube Year: 2016
- View Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT Year: 2016
Papers
- View High-Throughput Screening of Nav1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument Year: 2016
- View Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain Year: 2016
- View Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target Nav1.7 Year: 2015
- View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia Year: 2017
Reports
- View CHO-hNav1.7 assay on Qube pharmacology, biophysical characterization and the effect of internal fluoride Year: 2017
Nav1.8
Posters
Papers
- View Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia Year: 2017