Ion Channel Types - Psychiatric

Psychiatric disorders

Psychiatric disorders affect many people and encompasses a long list of conditions. The disorders range in severity from mild over socially debilitating to life threatening. A growing body of evidence has established that ion channels play an important role in these diseases. Neuronal excitability, neuro transmitter release, gene transcription and brain plasticity hinge on ion channel functionality and hence can be harmed by malfunctioning ion channels.

 

Selected ion channels involved in psychiatric disorders:

 

Key ion channels

Nav1.1, 1.2 & 1.3
Cav1.2
Kv1.1, 7.3 & 11.1
Kir3.1 & 4.1
KCa1.1 & 3.1
TASK3


Nav1.1, 1.2 and 1.3

Posters

  • View Biophysical and pharmacological characterization of multiple Nav subtypes on Qube
    Year: 2016 First author: Lindqvist et Al
  • View Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT
    Year: 2016 First author: Lindqvist et al., 2016
  • View Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques
    Year: 2012 First author: Schrøder et al., 2012
  • View Data quality is not affected by cell suspension density
    Year: 2006 First author: Mathes et al., 2006
  • View Evaluation of throughput and data quality
    Year: 2009 First author: Olsen et al., 2009
  • View Pharmacological characterization of voltage- and ligand-gated ion channels
    Year: 2006 First author: Olsen et al., 2006

Papers

  • View Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels
    Year: 2009 First author: Korsgaard et al., 2009
  • View Stable response for ligand and voltage-gated ion channels on QPatch
    Year: 2010 First author: Olsen et al., 2010
  • View QPatch: the missing link between HTS and ion channel drug discovery.
    Year: 2009 First author: Mathes
  • View Automated Patch Clamping Using the QPatch
    Year: 2009 First author: Jones et al. 2009
  • View A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo
    Year: 2017 First author: K Frederiksen

Reports

  • View Voltage-gated sodium channels on QPatch 16
    Year: 2012 First author: Olsen 2012

Cav1.2

Posters

  • View Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip
    Year: 2016 First author: Schupp et al., 2016
  • View Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques
    Year: 2012 First author: Schrøder et al., 2012

Papers

  • View A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
    Year: 2015 First author: Mistry et al., 2015
  • View Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
    Year: 2015 First author: Okada et al., 2015
  • View MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
    Year: 2013 First author: Kramer et al., 2013

Reports

  • View CHO Cav1.2 on QPatch (ChanTest)
    Year: 2011 First author: Friis et al., 2011
  • View Cav1.2 on Qube 384
    Year: 2017 First author: Schupp, M
  • View Cor.At cells embryonic stem cell derived cardiomyocytes on QPatch
    Year: 2009 First author: Schrøder et al., 2009

Kv1.1, 7.3 and 11.1

Posters

  • View Enhancing throughput with multiple cell lines per well
    First author: Olsen et al., 2006
  • View Strategies for enhancing throughput in ion channel drug screening
    Year: 2008 First author: Jacobsen et al., 2008
  • View Pharmacological characterization of voltage- and ligand-gated ion channels
    Year: 2006 First author: Olsen et al., 2006
  • View Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip
    Year: 2016 First author: Schupp et al., 2016
  • View Characterization of hERG blockers using the automated QPatch 16 screening system
    Year: 2005 First author: Jacobsen et al., 2005
  • View Data quality is not affected by cell suspension density
    Year: 2006 First author: Mathes et al., 2006
  • View “Clip Detecting” with series resistance compensation using an automated patch clamp system
    Year: 2012 First author: Løjkner et al., 2012

Papers

  • View Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium
    Year: 2010 First author: Al-Sabi et Al
  • View Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels
    Year: 2014 First author: Daly et al., 2014
  • View MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
    Year: 2013 First author: Kramer et al., 2013
  • View Characterization of Potassium Channel Modulators with QPatch™ Automated Patch-Clamp Technology: System Characteristics and Performance To cite this article:
    Year: 2004 First author: Kutchinsky et al., 2004
  • View Automated Patch Clamping Using the QPatch
    Year: 2009 First author: Jones et al. 2009
  • View Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels
    Year: 2009 First author: Korsgaard et al., 2009
  • View Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors
    Year: 2017 First author: Huang
  • View QPatch: the missing link between HTS and ion channel drug discovery.
    Year: 2009 First author: Mathes
  • View A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment
    Year: 2015 First author: Mistry et al., 2015
  • View Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
    Year: 2015 First author: Okada et al., 2015

Reports

  • View CHO-hERG Duo characterization and functional validation on QPatch
    Year: 2011 First author: Jacobsen et al., 2011
  • View CHO-hERG Duo in multi-hole mode on QPatch
    Year: 2011 First author: Jacobsen et al., 2011
  • View Stable response for ligand and voltage-gated ion channels on QPatch
    Year: 2010 First author: Olsen et al., 2010

Kir

Reports

  • View HEK-hKir2.1 on QPatch
    Year: 2013 First author: Olsen et al., 2013

Kca1.1 & 3.1

Papers

  • View Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators
    Year: 2013 First author: Jenkins et al., 2013
  • View New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1
    Year: 2014 First author: Coleman et al., 2014
  • View Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury
    Year: 2016 First author: Staala et al., 2016

Reports

  • View The intermediate conductance Ca2+ – activated K+ channel on Qube 384
    Year: 2017 First author: Sauter
  • View HEK293-KCa on QPatch
    Year: 2008 First author: Jacobsen et al., 2008

TASK

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