Other - Sophion

Channelopathies

Ion channels control many essential functions in the cell, including chemical signalling, regulation of pH, transcellular transport and regulation of cell volume. Abnormal function of ion channels can cause a diverse range of diseases, socalled channelopathies. The number of diseases related to ion channel malfunction are increasing and with that the amount of potential drugable ion channel targets.

 

A wide range of diseases are caused by ion channels

Examples of channelopathies are Cystic fibrosis (CFTRT, TMEM16), epilepsy (Kv7.2/KCNQ2), but ion channels are involved in diseases in many areas such as Cardiac, Genitourinary, Metabolic, Gastrointestinal, Stroke, Pain/Inflammation, Psychiatric Disorders, Pulmonary/Respiratory and Seizures/Convulsions. More and more evidence shows that ion channels could be a relevant target for cancer treatments as well.

 

Read more about automated patch clamping and channelopathies here

 


Reports

  • View Fast desensitizing ion channels recorded on Qube 384
    Year: 2017 First author: Sauter
  • View Fast series resistance compensation on Qube 384 and QPatch
    Year: 2016 First author: Jacobsen et al., 2016

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