(Transmembrane protein 16A, ANO1, CaCC)
TMEM16A (ANO1) is a Calcium activated Chloride channel (CaCC) that is involved in a plethora of physiological and pathophysiological conditions. The channel is suggested as target for treatment of asthma, secretory diarrheas, and hypertension, as well as an alternative to CFTR for treatment of Cystic Fibrosis. TMEM16A is unique as its gating synergistically depends on voltage and cytosolic Ca2+ (Scudieri et al. 2012).
- View TMEM16A on Qube Year: 2017